- In vivo MTD and PK studies designed with multiple treatment dose regimens, schedules, and delivery routes
- In vivo modeling for analysis of pharmacodynamic biomarkers
- In vivo efficacy testing of therapeutic agents in ectopic and orthotopic tumor models
- Efficacy studies in more clinically relevant models of advanced disease and metastases
- PDCellX models
- Human tumor cell culture-derived xenografts
- Syngeneic murine models
- Tumor growth and re-challenge
- Survival analysis
- In vivo imaging
- In vivo LDA assay
- Tumor recurrence post-excision of primary tumor or treatment interruption
- In vivo human skin graft model to study tumor and stromal cells
- In vivo models of angiogenesis, e.g. matrigel plug and human skin graft; CAM assay
- Analysis of tumor heterogeneity, initiation and tumorigenicity (e.g. cancer stem cells)
- Dissociation of tumor and tumor-infiltrating lymphocytes
- Ex-vivo downstream cellular analyses to complement in vivo efficacy results
In Vitro and ex-Vivo Tumor Cell Functional Assays
- Adhesion
- Migration
- Invasion
- Angiogenesis
- Tumor Initiation
- CAM assay
Immuno-oncology Models
Tissue sample dissociation and cell process for flow cytometry and others analyses; flow cytometry and immunophenotyping
Immunohistochemistry of Primary Tumors
Patient Tumor Biopsy
Patient-Derived Xenograft
Immunostaining of Tumor Cell Markers
Chick choriollantoic membrane (CAM) assay: analysis of pro-angiogenic and anti-angiogenic activities of tumor cells and treatments
Chimera Human-Mouse Skin Graft Model
Immunostaining of Human Tumors in Human Skin
Stained Human Blood Vessels in Human Skin
Chimera Human-Mouse Skin Graft Model
Immunostaining of Human Tumors in Human Skin
Stained Blood Vessels in Human Skin
Cell Adhesion
Cell Spreading
Tube Formation
All in vivo experiments are executed in compliance with approved SOPs and guidelines.
The facilities where the studies are conducted are ALAAAC accredited and registered with Office of Laboratory Animal Welfare (OLAW) and USDA. All experimental procedures are conducted under IACUC-approved protocols
