Welcome to Beviglia Cancer Models

The Preclinical Pharmacology Expertise on Demand

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Welcome
A Reliable Preclinical Service Provider for Your Pharmacology and Immuno-Oncology Projects
Scientific Consulting in Preclinical Tumor Modeling and Experimental Therapeutics

We are unique

We Are a Project Focused, "Niche" CRO

We are the perfect solution for biopharma built without a dedicated in vivo facility

We are your neighbor to conduct in vivo studies for your important projects

We Offer Exceptional Expertise in Tumor Biology and Pharmacology, Scientific Rigor, Diligence, Flexibility, Quick Turnaround, and Competitive Pricing

We Are Committed to Work Collaboratively with Clients on Model Selection, Protocol Improvement, Study Design and Execution

Our Tumor Models

PDCellXs and human or murine tumor cell culture-derived xenografts

Syngeneic murine models to evaluate innate immune response
Human tumor models in immunocompromised mice to study adaptive immunity (e.g. CAR-T cells).

Ectopic and Orthotopic

Melanoma, breast, lung, pancreas, colon, ovary, liver, prostate, and brain tumors

Hematological cancer (AML, ALL, CLL, MM)

Highly specialized surgical procedures, including excision of primary tumor, to mimic the clinical disease

Metastasis Models

Advanced disease with implant of tumor cells in the TME of origin

Spontaneous metastases with orthotopic implantation of tumor cells
Experimental metastases with injection of tumor cells in the blood circulation

Humanized Models

Human skin graft with intradermal implant of human tumors

Human immune cells engrafted models

Additional creative and innovative models tailored to the project needs
We Provide High Quality Data from Testing Efficacy of Cancer-Targeted and Immuno-Oncology Therapies in Clinically Predictive Tumor Models
We offer various in vivo study designs

Multiple treatment dose responses and schedules

PK and PD relationship modeling

Efficacy and PD biomarkers

  • Tumors, blood
  • Hair Follicles
  • Bone marrow
  • Skin and any other suitable tissues
We can test single agents and combination treatments
  • Small molecule compounds
  • Antibodies
  • Bispecifics
  • Immunotherapies
  • Immunomodulators
  • T-cell engagers
  • Checkpoint inhibitors
  • CAR-T cells

Metastasis Inhibition in Syngeneic Murine Models and PDCellXs

Measure of colony size and number
IHC and staining of cell markers
Primary Tumor Growth Inhibition and Tumor Relapse
Treatment interruption
Primary tumor surgical excision
Tumor Inhibition and Functional Analysis of Cell Subsets
Tumor and metastasis initiation
B16F10 Melanoma Cells
B16F10 Melanoma Cells
B16F10 Lung Metastases-Cell Titration
B16F10 Lung Metastases-Cell Titration
B16F10 Lung Metastases-Efficacy
B16F10 Lung Metastases-Efficacy
H&E-Lung Metastasis
H&E-Lung Metastasis
Immunostaining-Lung Metastasis
Immunostaining-Lung Metastasis
H&E-Liver Metastasis
H&E-Liver Metastasis
Primary Tumor Growth Inhibition
Primary Tumor Growth Inhibition
Tumor Initiation
Tumor Initiation
Metastasis Initiation
Metastasis Initiation

We also provide preclinical consulting

  • Review of experimental designs and protocols
  • Monitoring of studies
  • Data analysis and interpretation
  • Advice on organizational structure of in vivo facility
  • Management of study timelines
  • Provide guidelines and SOPs for a diligent study execution
Our competence and comprehensive knowledge of in vivo systems ensure diligent study design and execution to provide consistent and reproducible results, eliminate bias and artifacts, and decrease variability adding high values to our services.